Potentially Harmful Drug-Disease Interactions in the Elderly: Assesses adults 65 and older who have a specific disease or condition (chronic renal failure, dementia, history of falls) and were dispensed a prescription for a medication that could exacerbate it.
Use of High-Risk Medications in the Elderly: Assesses adults 65 and older who had at least one dispensing event for a high-risk medication or who had at least 2 dispensing events for the same high-risk medication.
Why It Matters
Prescription drug use by the elderly can often result in adverse drug events that contribute to hospitalization, increased duration of illness, nursing home placement, falls and fractures. Despite widely accepted medical consensus that certain drugs increase the risk of harm to the elderly, these drugs continue to be prescribed.
Because older adults are more likely to take multiple medications for multiple conditions, they are also at higher risk of potentially harmful drug-disease interactions. Avoiding the use of high-risk drugs is an important, simple and effective strategy to reduce medication-related problems and adverse drug events in older adults.
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- Fick, D.M., et al. 2003. “Updating the Beers criteria for potentially inappropriate medication use in older adults.” Arch Intern Med 163:2716–24.
- Radcliff, S., J. Yue, G. Rocco, S.E. Aiello, E. Ickowicz, Z. Hurd, M.J. Samuel, M.J., and M.H. Beers. 2015. “American Geriatrics Society 2015 updated beers criteria for potentially inappropriate medication use in older adults.” Journal of the American Geriatrics Society 63(11): 2227–46.