Non-Recommended PSA-Based Screening in Older Men (PSA)

The percentage of men 70 years and older who were screened unnecessarily for prostate cancer using prostate-specific antigen (PSA)-based screening. 

Why it Matters

The current lifetime risk for a male to develop prostate cancer is 11% and the risk of dying from it is 2.5%. The primary test used to screen for prostate cancer is the PSA blood test, which evaluates the presence of an antigen in a patient’s blood. However, there are a variety of issues associated with PSA-based screening. The PSA test may produce false-positive results, which would lead to unnecessary follow-up treatment and testing. The main harms result from complications due to biopsies and treatment that typically follow abnormal results. False-positive results and complications are more common in older men1. Prostate cancer is also subject to overdiagnosis, the detection of a condition that would have remained silent and caused no morbidity during a patient’s lifetime. Studies estimate overdiagnosis rates from 20%–50%2. 

For this measure, a lower rate indicates better performance. 

*Adapted with financial support from the Centers for Medicare & Medicaid Services (CMS)

Historical Results – National Averages

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References

  1. USPSTF, D.C. Grossman, S.J. Curry, D.K. Owens, K. Bibbins-Domingo, A.B. Caughey, K.W. Davidson, et al. 2018. “Screening for Prostate Cancer: U.S. Preventive Services Task Force Recommendation Statement.” JAMA 319 (18): 1901–13. https://doi.org/10.1001/jama.2018.3710
  2. Fenton, J.J., M.S. Weyrich, S. Durbin, Y. Liu, H. Bang, and J. Melnikow. 2018. “Prostate-Specific Antigen-Based Screening for Prostate Cancer: A Systematic Evidence Review for the U.S. Preventive Services Task Force.” U.S. Preventive Services Task Force Evidence Syntheses, Formerly Systematic Evidence Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US). http://www.ncbi.nlm.nih.gov/books/NBK518890/

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